Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 9-jild 5-son (2024)
MONITORING OF HEMATOLOGICAL INDICES IN PREDICTING OUTCOMES IN CEREBROVASCULAR CRITICAL CONDITIONS
САБИРОВ Джурабай Марифбаевич, ЭШОНОВ Олим Шоимкулович, БАТИРОВ Улугбек Бешимович, ХАЙДАРОВА Сирануш Эдуардовна
Annotatsiya
Aim. Determination of the prognostic assessment of the index of the number of neutrophils to lymphocytes in the blood in patients with cerebral strokes. Material and methods. The materials of discussion and analysis were the results of examination and complex treatment of 28 patients with acute cerebral insufficiency (complication of ischemic and hemorrhagic stroke) aged from 32 to 65 years (the average age was 56.3 ± 3 years). The research program, in addition to general clinical studies, included special research methods that allow an adequate assessment of the immune status (leukoformula, ISNL), which further made it possible to predict the outcome and effectiveness of the therapy. Comparison of clinical and laboratory parameters was carried out in three stages: the first stage - upon admission, the second stage: – the 3rd day, the third stage - the 7th day of intensive care. Results. The presented data show that in both forms of stroke there is a unidirectional trend of changes, such as the predictive indicator of ISNL in peripheral blood. At the same time, the most pronounced changes with a more progressive deterioration in the neurological status occur in hemorrhagic strokes. Laboratory parameters of patients who were in a coma for a long time showed a progressive increase in the number of segmented neutrophils, and the number of lymphocytes was below 10, respectively, an increase in the ISNL index was above 3.5. Conclusion. It was found that a high rate of ISNL is a reliable indicator of the clinical deterioration of patients and a predictor of an unfavorable outcome of critical conditions caused by acute cerebral insufficiency.
ишемический и геморрагический инсульт, лейкоформула иммунная системаischemic and hemorrhagic stroke, leukoformula, immune system
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