Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Том 9 № 5 (2024)
S100 PROTEIN EXPRESSION AND THEIR SIGNIFICANCE IN DISSEMINATED BREAST CANCER
РАХИМОВ Нодир Махамматкулович, ШАХАНОВА Шахноза Шавкатовна, РАХМОНОВ Камол Аминжонович
Аннотация
S100 proteins are small calcium-binding molecules with a specific EF-hand structure. These proteins are found throughout vertebrate bodies and serve many vital functions. Different cell types contain specific sets of S100 proteins, which ensures their targeted action. Inside cells, S100 proteins control various enzymes and other proteins. Outside cells, they work as messenger molecules carrying signals between cells. S100 proteins manage calcium levels and affect how cells divide, mature, and die. During tumor growth, S100 protein levels often change. Higher levels of certain S100 family members are found in breast cancer, lung cancer, and melanoma. These proteins also play a role in inflammation and some nervous system disorders. Doctors measure S100 protein levels to diagnose various diseases. Scientists are creating drugs that target these proteins to treat cancer and other illnesses. However, we still don't fully understand how S100 proteins work. Currently, researchers are studying how S100 proteins affect breast cancer. They aim to develop new treatments by controlling these proteins' activity. Their findings could lead to better ways to fight cancer. Research shows that S100 proteins can both increase and decrease inflammation. This makes them promising targets for anti-inflammatory drugs. More research is needed to fully understand these unique proteins' role in the body. This translation maintains the key information while using clear, direct language and avoiding abstract concepts. It's structured in short, focused paragraphs that each address a specific aspect of S100 proteins and their relationship to breast cancer.
S100 белки, Ca2+-зависимая сигнализация, биомаркеры, противораковая терапияS100 proteins, Ca2+-dependent signaling, biomarkers, anti-cancer therapyS100 oqsillari, kalsiyga bog'liq signalizatsiya, biomarkerlar, saratonga qarshi davolash
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