Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 9-том 5-нөмір (2024)
STUDY OF THE TOXICOLOGY OF THE ANTITUMOR DRUG Colchiprit-neo (K-20)
УРОЗОВ Нуриддин Элмуротович, ВЫПОВА Наталья Леонидовна, НИШАНОВ Даниер Анарбаевич, МАДАЛИЕВ Ахрор Алиевич, ИБРАГИМОВ Шавкат Нарзикулович, ЕНИКЕЕВА Зульфия Махмудовна
Аңдатпа
The study of the chronic toxicity of the drug Colchiprit-neo in rats with oral administration at doses of 30.0, 61.0 and 120 mg/kg for 30 days was carried out. It has been shown that with repeated oral administration to rats, the drug does not affect the behavior and weight dynamics of animals, does not have a toxic effect on the composition of peripheral blood, kidney function, but increases AlAt in the liver, however, after 1 month of the recovery period, all these indicators changed within the physiological norm. A pathomorphological study of the internal organs of rats showed that when applying a dose of 30 mg / kg, toxicity does not manifest itself when affecting the internal parenchymal organs. All the above data allow us to conclude that the drug in a therapeutic dose does not have a toxic effect on the animal body.
препарат Колхиприт-нео», пероральное введение, хроническая токсичностьColchiprit-neo drug, oral administration, chronic toxicity
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