Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 9-том 6-нөмір (2024)
MODERN VIEW ON THE PROBLEM OF DIAGNOSIS IN PATIENTS WITH ANGIOFIBROMA OF THE NASOPHARYNX BY DETECTING POLYMORPHISM OF THE GSTM1 GENE
ХАМРАКУЛОВА Наргиза Орзуевна, КАЗИМОВ Бекзод Батырович
Аңдатпа
Nasopharyngeal angiofibroma is a rare but potentially dangerous disease that requires accurate diagnosis and effective treatment methods. Current diagnostic approaches are mainly based on visual and morphological techniques, but the use of molecular markers, such as GSTM1 gene polymorphism, opens new perspectives in this field. Genes involved in xenobiotic metabolism and antioxidant defense play a role in the development of tumor diseases, including angiofibroma. The GSTM1 gene polymorphism, specifically its deletion, may be associated with an increased risk of tumor development, highlighting its significance as a diagnostic marker. This review presents an overview of the current diagnostic methods for nasopharyngeal angiofibroma and discusses the potential applications of GSTM1 polymorphism in improving prognosis, individualizing treatment, and enhancing therapeutic effectiveness. Further research on the role of this genetic marker in the disease pathogenesis is recommended, as well as its integration into clinical practice for more precise diagnosis and the development of personalized treatment approaches.
ангиофиброма носоглотки, полиморфизм гена GSTM1, метаболизм ксенобиотиков, антиоксидантная защита, молекулярные маркеры, индивидуализация лечения.nasopharyngeal angiofibroma, GSTM1 gene polymorphism, xenobiotic metabolism, antioxidant defense, molecular markers, personalized treatmentnazofaringial angiofibroma, GSTM1 geni polimorfizmi, ksenobiotiklar metabolizmi, antioksidant himoya, molekulyar markerlar, individual davolash
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