Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 10-том 1-сан (2025)
CLINICAL FEATURES OF PARKINSON'S DISEASE IN THYROID HOMEOSTASIS DISRUPTION
ХАКИМОВА Сохиба Зиядуллоевна, ГАФФАРОВА Парвина Абдурафиковна, АБРУЙЕВ Худоёрхон Ойбекович
Аннотация
Purpose: to study the influence of thyroid homeostasis disorders on the development of Parkinson's disease and dementia. Methods: The study employed clinical-neurological methods, laboratory indicators (TSH, TRH, T3, T4), neuroimaging techniques, neurological assessments (the Hoehn and Yahr scale, UPDRS), the MMSE (Mini-Mental State Examination), and methods of multivariate statistical analysis. Results: The tremor-dominant form of Parkinson's disease is associated with lower levels of TSH (thyroid-stimulating hormone) compared to the akinetic-rigid type. Higher levels of T3 are correlated with less severe manifestations of the disease. The degradation of dopaminergic neurons, along with an imbalance in TRH (thyrotropin-releasing hormone) levels, may contribute to motor dysfunction and tremors in patients with Parkinson's disease. Furthermore, both hypothyroidism and hyperthyroidism are linked to increased oxidative stress, which disrupts the dopamine system and leads to neuronal apoptosis, potentially resulting in dementia. Conclusion. Thus, in the first control group of patients with Parkinson's disease (PD) and hypothyroidism, compared to the second control group consisting solely of PD patients, there were progressive symptoms such as increased tremor and cognitive dysfunction. These symptoms may be related to the interaction between PD and hypothyroidism. Assessing the dynamics of motor and cognitive impairments at various stages of the disease allows for timely correction of motor disorders in collaboration with endocrinologists and neurologists, as well as stabilization of the disease course. It is recommended that patients with PD be screened for hypothyroidism, and that patients with hypothyroidism be evaluated for PD.
тиреоидный гомеостаз, нейродегенеративные заболевания, ЭМГ, MMSE тестthyroid homeostasis, neurodegenerative diseases, EMG, MMSE testтиреоид гомеостаз, нейродегенератив касалликлар, ЭМГ, MMSE тест
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