Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 10-том 1-сан (2025)
THE ROLE OF IMMUNE STATUS IN THE PATHOGENESIS OF RECURRENT APHTHOUS STOMATITIS
Наврўзова Угилхон Орзижон қизи, Хабибова Назира Насуллаевана
Аннотация
The article is devoted to the study of immune status in patients with recurrent aphthous stomatitis (RAS). An analysis of specific and nonspecific factors of local immune response, including lactoferrin, immunoglobulins (IgA, IgM, IgG), interferon-γ, interleukins (IL-2, IL-4), and tumor necrosis factor-α (TNF-α), was carried out. A significant increase in the concentrations of immunoglobulins and TNF-α was found, accompanied by a decrease in interferon-γ and IL-4. These changes indicate the activation of inflammatory processes, tissue destructive changes, and weakened antiviral protection of the mucosa. The obtained results emphasize the pathogenetic significance of local immunity in the development of RAS and substantiate the need to include immunomodulatory therapy in comprehensive treatment.
хронический рецидивирующий афтозный стоматит, иммунный статус, лактоферрин, интерлейкины, интерферон-γ, фактор некроза опухолей-α, иммуноглобулины, воспаление, локальный иммунитетrecurrent aphthous stomatitis, immune status, lactoferrin, interleukins, interferon-γ, tumor necrosis factor-α, immunoglobulins, inflammation, local immunityretseptiv aftöz stomatit, immun maqomi, laktoferrin, interleykinlar, interferon-γ, o'sma nekroz omili-α, immunoglobulinlar, yallig'lanish, mahalliy immunitet
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