Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Volume 10 Issue 1 (2025)
COMPARISON OF ALLELE AND GENOTYPE FREQUENCIES OF THE UMOD GENE POLYMORPHISM RS4293393 BETWEEN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS AND A CONTROL GROUP
ТАШКЕНБАЕВА Элеонора Негматовна, ЕСАНКУЛОВ Мухаммад Олимович
Abstract
This study focuses on the comparative analysis of allele and genotype frequencies of the UMOD gene polymorphic marker rs4293393 in patients with chronic glomerulonephritis (CGN) and a control group. The aim is to identify potential associations between allelic variants and the risk of CGN. Data collection and analysis revealed the distribution of alleles C and T among patients and controls. Allele C was found more frequently in patients with CGN than in the control group (30.91% vs. 25.84%, OR = 1.28, 95% CI: 0.80–2.05), though statistical significance was not achieved (p = 0.356). Conversely, allele T was less frequent among patients (69.09% vs. 74.16%, OR = 0.78, 95% CI: 0.49–1.24), also without statistical significance (p = 0.356). The results suggest a weak association between the UMOD rs4293393 polymorphism and CGN risk, warranting further research for confirmation.
ген UMOD, rs4293393, хронический гломерулонефрит, частота аллелей, распределение генотипов, полиморфизм, генетическая ассоциация, оценка рискаUMOD gene, rs4293393, chronic glomerulonephritis, allele frequency, genotype distribution, polymorphism, genetic association, risk assessmentUMOD geni, rs4293393, surunkali glomerulonefrit, allel chastotasi, genotip taqsimoti, polimorfizm, genetik bog‘liqlik, xavfni baholash
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