Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Volume 10 Issue 3 (2025)
GENETIC POLYMORPHISM OF PGR (RS1042838) AND ITS ASSOCIATION WITH VARIOUS CLINICAL FORMS OF GENITAL PROLAPSE
НАСИМОВА Нигина Рустамовна, ДАВРАНОВА Лобар Саидовна
Abstract
The relationship between various clinical forms of genital prolapse and the progesterone receptor gene PGR (rs1042838) polymorphism was studied in sick women. Genetic analysis was performed on DNA samples using the standard PCR method. The results of the complex analysis showed clear trends in the distribution of alleles and genotypes in the PGR (rs1042838) gene. In particular, it was found that carriers of alleles and genotypes that have a negative prognostic significance in cases of pelvic floor insufficiency with genital prolapse have a statistically significant higher risk of developing the disease and the likelihood of its worsening.
пролапс гениталий, рецептор прогестерона, полиморфизм, ген, PGR (rs1042838), частота, аллель, генотип, носители.genital prolapse, progesterone receptors, polymorphism, gene, PGR (rs1042838), frequency, allele, genotype, carriers.genital prolaps, progesteron retseptorlari, polimorfizm, gen, PGR (rs1042838), chastota, allel, genotip, tashuvchilar.
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