Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Volume 10 Issue 3 (2025)

DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER

NORBEKOVA Munira Hamroqulovna, ALIMHODJAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Xusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, MIRZAYEVA Matluba Akbarali kizi

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Abstract

The aim of the study: To analyze the molecular-biological characteristics of primary and secondary tumors in patients with breast cancer (BC). Material and methods: A retrospective analysis of data from 133 patients treated at the Republican Specialized Scientific and Practical Center of Oncology and Radiology and its branches during 2018-2023 was conducted. Histological and immunohistochemical analyses were performed. Results: When immunohistochemical (IHC) analysis was performed on the primary and secondary tumor nodules, it was confirmed that in cases where ER and PR receptors were not detected in the primary nodule, hormone receptors were positive in the secondary nodule. (p-0.05) Conclusion: If hormone receptors are negative in the primary nodule, it is recommended to perform IHC analysis on the secondary nodule. This is a factor that determines the possibility of including hormone therapy in treatment programs.

multicentric, multifocal, breast cancer, histological examination, immunohistochemistry, hormone receptorsmultisentrik, ko’p o’choqli, sut bezi saratoni, gistologik tekshiruv, immunogistokimyo, gormon retseptorlari

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APA 7 
NORBEKOVA Munira Hamroqulovna, ALIMHODJAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Xusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna & MIRZAYEVA Matluba Akbarali kizi (2025). DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3).
GOST R 7.0.5 
NORBEKOVA Munira Hamroqulovna, ALIMHODJAYEVA Lola Telmanovna, OTAJONOV Jamoliddin Xusanovich, ZIYAVEDENOVA Soniyakhon Saidaalo kizi, KHUSANOVA Mohinabonu Jamoliddinovna, MIRZAYEVA Matluba Akbarali kizi DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2025. Т. 10. № 3.
BibTeX 
@article{hamroqulovna2025,
  author  = {NORBEKOVA Munira Hamroqulovna and ALIMHODJAYEVA Lola Telmanovna and OTAJONOV Jamoliddin Xusanovich and ZIYAVEDENOVA Soniyakhon Saidaalo kizi and KHUSANOVA Mohinabonu Jamoliddinovna and MIRZAYEVA Matluba Akbarali kizi},
  title   = {DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2025},
  volume  = {10},
  number  = {3}
}
RIS 
TY  - JOUR
AU  - NORBEKOVA Munira Hamroqulovna
AU  - ALIMHODJAYEVA Lola Telmanovna
AU  - OTAJONOV Jamoliddin Xusanovich
AU  - ZIYAVEDENOVA Soniyakhon Saidaalo kizi
AU  - KHUSANOVA Mohinabonu Jamoliddinovna
AU  - MIRZAYEVA Matluba Akbarali kizi
TI  - DIFFERENCES IN HORMONE RECEPTOR STATUS BETWEEN PRIMARY AND SECONDARY TUMOR NODULES IN MULTIFOCAL BREAST CANCER
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2025
VL  - 10
IS  - 3
ER  -