Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 10-jild 4-son (2025)
MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL METHODS IN VERIFICATION OF NON-MUSCLE INVASIVE BLADDER CANCER
АЛЛАЗОВ Искандар Саллах угли, АЛЛАЗОВ Саллах Аллазович, АЛЛАЗОВ Феруз Ниёзович, Мадалимов Ахрор Алиевич
Annotatsiya
The article provides a comprehensive review of contemporary diagnostic approaches in bladder cancer (BC) verification, focusing on morphological and immunohistochemical (IHC) methods over the past 5-7 years. The research synthesizes current strategies for molecular subtyping and prognostic assessment of non-muscle invasive bladder cancer (NMIBC). The study analyzes key IHC markers (GATA3, CK7, CK20, Ki-67, p53, p16, Uroplakin III) that enable precise tumor characterization and molecular profiling. Special attention is given to the diagnostic potential of proliferative markers and their correlation with tumor aggressiveness, progression risk, and clinical outcomes. The authors emphasize the critical role of integrated morphological and IHC approaches in improving diagnostic accuracy, patient stratification, and personalized treatment selection. The research highlights the importance of comprehensive marker panels in identifying molecular subtypes and predicting disease progression, particularly in NMIBC. Key findings demonstrate that advanced IHC techniques provide crucial insights into tumor biology, enabling more targeted therapeutic strategies and improving patient management. The study concludes by underlining the need for standardized diagnostic protocols and continued research in molecular oncology.
рак мочевого пузыря, морфология, ИГХ, методы диагностикиbladder cancer, morphology, immunohistochemically, diagnostic approachesқовуқ саратони, морфология, ИГХ, диагностик текширув
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