Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Ҷилди 11 № 1 (2026)
DIAGNOSTIC VALUE OF INFLAMMATORY PROCESSES IN DIFFERENTIATING PARKINSONISM SUBTYPES
МАНСУРОВА Наргиза Асроровна
Аннотатсия
The role of neuroinflammatory processes and the gut-brain axis in the pathogenesis of Parkinson's disease and other forms of parkinsonism has emerged as a priority research area in contemporary neurology. This study aimed to comprehensively evaluate systemic and intestinal inflammation in patients with Parkinson's disease and vascular parkinsonism through assessment of interleukin-6 (IL-6), fecal calprotectin levels, and Helicobacter pylori infection status, while analyzing their associations with clinical manifestations and disease progression. The findings demonstrated significantly elevated IL-6 and fecal calprotectin levels in Parkinson's disease patients compared to those with vascular parkinsonism, indicating more pronounced systemic and intestinal inflammatory responses. Statistically significant correlations were established between inflammatory biomarkers, severity of motor dysfunction, and clinical disease stage. The higher prevalence of Helicobacter pylori infection in Parkinson's disease patients and its correlation with clinical parameters confirm the pathogenetic significance of infectious factors in triggering the inflammatory cascade. These results provide evidence for the critical pathogenetic role of the gut-brain axis in Parkinson's disease development and reveal promising applications of inflammatory markers in differential diagnosis, risk stratification, and development of personalized therapeutic strategies.
болезнь Паркинсона, паркинсонизм, ось «кишечник–мозг», интерлейкин-6, фекальный кальпротектин, Helicobacter pylori, нейровоспалениеParkinson's disease, parkinsonism, gut-brain axis, interleukin-6, fecal calprotectin, Helicobacter pylori, neuroinflammationПаркинсон касаллиги, паркинсонизм, ичак-мия ўқи, интерлейкин-6, фекал калпротектин, Helicobacter pylori, нейрояллиғланиш
Манбаи метамаълумот: бойгонии OAI-PMH-и маҷалла · Sindex матни пурраро нигоҳ намедорад, ба манбаъ пайванд медиҳад.