Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 11-том 1-нөмір (2026)
CORRECTION OF DEPRESSIVE DISORDERS AND EVALUATION OF THE EFFECTIVENESS OF COMPREHENSIVE REHABILITATION IN PATIENTS WITH CHEMICAL ADDICTIVE DISORDERS
ОЧИЛОВ Улугбек Усманович, ТУРАЕВ Бобир Темирпулотович, СУЛТАНОВ Шохрух Хабибуллаевич
Аңдатпа
Purpose: Identification of depressive disorders in patients with chemical addictive disorders and enhancement of the effectiveness of the rehabilitation process through their management. Material and methods: The study was conducted in 2024–2025 at the Samarkand branch of the Republican Specialized Scientific-Practical Medical Center for Mental Health. Based on clinical and psychometric assessments, 200 patients diagnosed with psychoactive substance dependence and having chemical addictive disorders were studied. Among them, 61% had alcohol dependence, 24% opioid dependence, 9% synthetic cannabinoid use, and 6% psychostimulant dependence. Patients with depressive symptoms were randomly divided into two groups: the main group (n=100) received a combined approach (SSRI + Cognitive Behavioral Therapy (CBT) + Motivational Interviewing (MI)), while the comparison group (n=100) received only SSRI treatment. Depressive symptoms were assessed using HDRS, BDI, and HADS scales. Evaluation was conducted at three stages: before rehabilitation, after 3 months, and at a 6-month follow-up. Results: The main group showed a significant reduction in depressive symptoms across all scales: BDI scores decreased from 25,1 ± 3,0 to 8,4 ± 1,9, HDRS from 27,8 ± 4,3 to 7,9 ± 2,2, and HADS depression subscale from 13,8 ± 2,0 to 4,4 ± 1,1 (p < 0,001). While improvement was also observed in the comparison group, the changes were significantly less pronounced (p < 0,005). Conclusion: In patients with chemical addictive disorders, a comprehensive (pharmacological and psychotherapeutic) approach is more effective in correcting depressive disorders and ensures a higher-quality and more stable rehabilitation process.
химическое аддиктивное расстройство, психоактивные вещества, зависимость, депрессия, реабилитация, когнитивно-поведенческая терапия, мотивационное интервьюирование, ИОЗСchemical addictive disorder, psychoactive substance, dependence, depression, rehabilitation, cognitive behavioral therapy, motivational interviewing, SSRIkimyoviy addiktiv buzilish, psixoaktiv modda, qaramlik, depressiya, reabilitatsiya, kognitiv xulq-atvor terapiyasi, motivatsion intervyu, SSRI
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