Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 11-том 3-сан (2026)
A POPULATION-BASED APPROACH TO CERVICAL CANCER: THE CONTEMPORARY IMPORTANCE OF CANCER REGISTRIES, SCREENING, AND SURVIVAL ANALYSIS
ЮСУПБЕКОВ Аброрбек Ахмеджанович, ТУЙЧИЕВА Сабохат Шавкатовна, ДЖАНКЛИЧ Саиде Мустафаевна
Аннотация
This narrative review highlights the contemporary importance of a population-based approach to cervical cancer (CC). We summarize global and regional epidemiologic patterns of CC, the etiologic role of high-risk human papillomavirus (HPV), major risk factors, and the prevention framework built on HPV vaccination, organized screening, and early diagnosis. Cancer registries are discussed as the core information infrastructure for cancer control, including their definition, main types, and their value for surveillance, planning, and evaluation. The role of international standards and registry networks (IARC/IACR, ENCR, SEER, NPCR) and global initiatives such as Cancer Incidence in Five Continents (CI5) is outlined with regard to data comparability, quality assurance, and cross-country benchmarking. We also address the organization of oncology services in Uzbekistan and the limitations of aggregated official reporting for robust outcome assessment. Strengthening the population-based cancer registry, implementing systematic data quality control, ensuring continuous follow-up, and integrating registry data with mortality and screening databases are emphasized as prerequisites for valid population survival estimates. Key survival metrics (overall, relative, and net survival), common analytical approaches, and interpretation issues are briefly reviewed. Evidence from EUROCARE and CONCORD demonstrates that international differences in CC survival largely reflect screening coverage and the completeness and quality of registry data.
рак шейки матки; популяционный подход; канцер-регистрcervical cancer; population-based approach; cancer registry; screening; HPV; survivalбачадон бўйни саратони; популяцион ёндашув; канцер-регистр; скрининг; HPV; яшовчанлик
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