Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 11-том 2-сан (2026)
METABOLIC DISORDERS AND THE RISK OF MULTIMORBIDITY IN PATIENTS WITH COPD
ФАТТАХОВ Рафкат Акрамович
Аннотация
Abstract. Chronic obstructive pulmonary disease is regarded as a systemic metabolic-inflammatory disorder in which comorbid conditions substantially determine disease severity, functional limitations, and adverse prognosis [11, 13]. The aim of the study was to assess the pattern of metabolic disturbances in patients with chronic obstructive pulmonary disease and to determine their significance in the development of multimorbidity risk. The study was based on the examination results of 100 patients with COPD aged 38–82 years, of whom 81.0% had stage III–IV disease. It was established that, as COPD severity increased, hyperglycemia, insulin resistance, atherogenic dyslipidemia, C-reactive protein, and uric acid levels also increased, whereas body mass index decreased at advanced stages, leading to the formation of a catabolic phenotype. Comorbidity was identified in 76.0% of the examined patients and was associated with more severe dyspnea, higher CAT scores, lower FEV1 values, and more pronounced disturbances in the metabolic profile. The most significant predictors of multimorbidity risk were hs-CRP ≥3.0 mg/L and uric acid ≥6.0 mg/dL (OR=3.1), HOMA-IR >2.5 (OR=2.7), atherogenic coefficient ≥4.0 (OR=2.6), and fibrinogen ≥4.0 g/L (OR=2.5). A combined model including HOMA-IR, CRP, and triglycerides demonstrated high predictive accuracy (AUC=0.89; sensitivity 86.8%; specificity 83.3%).
ХОБЛ, метаболические нарушения, ИМТ, CAT, GOLD, мультиморбидность, коморбидность, HOMA-IR, дислипидемия, С-реактивный белок, ROC-анализ.COPD, metabolic disorders, BMI, CAT, GOLD, multimorbidity, comorbidity, HOMA-IR, dyslipidemia, C-reactive protein, ROC analysisSO‘OK, metabolik buzilishlar, TVI, CAT, GOLD, multimorbidlik, komorbidlik, HOMA-IR, dislipidemiya, C-reaktiv oqsil, ROC-tahlil
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