Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Volume 11 Issue 3 (2026)
FEATURES OF METABOLIC AND INFLAMMATORY MARKERS IN DIFFERENT CLINICAL AND LABORATORY PHENOTYPES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
ХАЙДАРОВА Феруза Алимовна, ОЙХУДЖАЕВА Камила Фарруховна, ИСОМИДДИНОВ Алижон Олимжон угли, БЕГМАТОВА Хафиза Аширметовна, ДУШАМОВА Мехрибон Шавкатовна
Abstract
Objective. To evaluate the clinical and laboratory characteristics of four chronic kidney disease (CKD) phenotypes in patients with type 2 diabetes mellitus (T2DM) according to estimated glomerular filtration rate (eGFR) and albuminuria status. Materials and Methods. This prospective cross-sectional study included 153 patients with T2DM stratified into four groups: NRF/NA (normal renal function/normoalbuminuria, n=35), DRF/NA (decreased renal function/normoalbuminuria, n=35), NRF/EA (normal renal function/elevated albuminuria, n=35), and DRF/EA (decreased renal function/elevated albuminuria, n=30). The control group consisted of 18 healthy individuals. Demographic, anthropometric, glycemic, lipid, inflammatory, and coagulation parameters were assessed. Results. The groups differed significantly in age (p<0.001), blood pressure levels, markers of renal function, carbohydrate metabolism indices, and inflammatory parameters. The highest C-reactive protein (CRP) levels (24.5±13.1 mg/L) were observed in the NRF/EA group. In the same group, cystatin C reached 5.79±2.0 mg/L despite formally normal eGFR values. The prothrombin index was significantly elevated in groups with albuminuria. BMP-7 levels did not differ significantly between the groups (p=0.080); however, BMP-7 showed a positive correlation with C-peptide (ρ=0.176; p=0.030). Conclusion. CKD phenotyping in T2DM based on two axes (eGFR and albuminuria) reveals heterogeneity of pathogenic mechanisms, which has practical implications for personalized nephroprotective therapy. The NRF/EA phenotype is characterized by a predominance of pro-inflammatory and procoagulant features accompanied by subclinical tubular dysfunction.
сахарный диабет 2 типа; хроническая болезнь почек; диабетическая нефропатия; BMP-7; цистатин С; альбуминурия; скорость клубочковой фильтрации; С-реактивный белокtype 2 diabetes mellitus; chronic kidney disease; diabetic nephropathy; BMP-7; cystatin C; albuminuria; glomerular filtration rate; C-reactive protein2-tip qandli diabet; buyrak surunkali kasalligi; diabetik nefropatiya; BMP-7; sistatin C; albuminuriya; koptokchali filtratsiya tezligi; C-reaktiv oqsil
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