Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Volume 11 Issue 3 (2026)

THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY

МАМАДИЯРОВА Дилшода Умирзоковна, АЗИМОВА Севара Баходировна

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Abstract

The GPX4 gene (located at 19p13.3) is located in the 3' untranslated region (3'UTR), and the functionally significant C718T (rs713041) polymorphism is highly associated with diabetes mellitus. Mutations in this regulatory region are known to affect messenger RNA (mRNA) stability, translation efficiency, and ultimately the concentration of active enzyme in the cell. Substitution of cytosine (C) for thymine (T) is associated with decreased GPX4 enzyme activity. This article presents important aspects of this gene in patients with diabetic angiopathy.

Ген GPX4, полиморфизм C718T (RS713041), диабетическая ангиопатия, окислительная система, антиоксидантная система, повреждение сосудовGPX4 gene, C718T (RS713041) polymorphism, diabetic angiopathy, oxidative system, antioxidant system, vascular damageGPX4 geni, C718T (RS713041) polimorfizmi, diabetik angiopatiya, oksidlovchi tizim, antioksidant tizim, qon-tomir shikastlanishi

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Cite

APA 7 
МАМАДИЯРОВА Дилшода Умирзоковна & АЗИМОВА Севара Баходировна (2026). THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3).
GOST R 7.0.5 
МАМАДИЯРОВА Дилшода Умирзоковна, АЗИМОВА Севара Баходировна THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2026. Т. 11. № 3.
BibTeX 
@article{умирзоковна2026,
  author  = {МАМАДИЯРОВА Дилшода Умирзоковна and АЗИМОВА Севара Баходировна},
  title   = {THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2026},
  volume  = {11},
  number  = {3}
}
RIS 
TY  - JOUR
AU  - МАМАДИЯРОВА Дилшода Умирзоковна
AU  - АЗИМОВА Севара Баходировна
TI  - THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2026
VL  - 11
IS  - 3
ER  -