Innovations in Science and Technologies Том 1 № 1 (2024) · с. 28-36
DIMETALATION OF BIS-CARBAMATE MEE-1 AND IN SILICO STUDY OF PHYSICOCHEMICAL PARAMETERS
Mashaev, Eldor, Pulatov, Khayrulla, Yuldashev, Alisher
Аннотация
This scientific work is devoted to the dimetalation of N,N'-hexamethylene bis-[(ortho-cresolyl)-carbamate] and the synthesis of N,N'- disodium, N,N'-hexamethylene bis-[(ortho-cresolyl)-carbamate] i.e. MEE-1b. As a result, distrium substituted bis-carbamate MEE-1b was obtained in high yield. In silico primary screenings were carried out to study the elemental composition, some physicochemical properties and biological activities. As a result, it was revealed that bis-carbamate MEE-1b can be used as an inhibitor and substrate of cytochrome. And also in the treatment of phobic disorders. Further study in real in vitro and in vivo analyzes is also recommended.
Bis-carbamate, pass online, screening, sodium, activity, inhibitor, substrate, phobic, cytochrome.
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