Innovation science and technologiy Volume 2 Issue 1 (2026)
CLINICAL ASSESSMENT OF THE STATE OF LOCAL IMMUNE MECHANISMS OF THE ORAL CAVITY IN PATIENTS AT DIFFERENT STAGES OF ORTHODONTIC TREATMENT
Rakhimberdiev, Rustam, Saifulaeva, Aziza
Abstract
This article presents the results of a clinical observation aimed at studying the response of local immunemechanisms in the oral cavity of patients undergoing orthodontic treatment using fixed orthodontic appliances. A total of147 patients aged 21–29 years were examined. Unstimulated oral fluid was used as the study material, in which lysozymeactivity, secretory immunoglobulin A levels, and interleukin-1β and interleukin-4 concentrations were determined. Theresults demonstrated that fixation of orthodontic appliances is accompanied by changes in the immunological profileof oral fluid, reflecting the development of an adaptive inflammatory response. The application of extended preventivemeasures contributes to a more favorable course of the adaptation period and promotes restoration of local immunebalance.
orthodontic treatment, oral fluid, local immunity, immunological parameters, inflammation.
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