Жанубий оролбўйи тиббиёт журнали Том 1 № 3 (2025) · с. 261-270

MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF LUNG TISSUE IN NEWBORNS BORN TO MOTHERS INFECTED WITH COVID-19

Karimov, Rasulbek, Tajibayeva, Ma’mura

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Аннотация

Neonatal SARS-CoV-2 infeksiyasi kam uchrashi bilan birga, vertikal yoki perinatal yuqish holatlarida o‘pkada xarakterli morfologik va immunologik o‘zgarishlar namoyon bo‘lishi mumkin. Ushbu tadqiqotda COVID-19 musbat onalardan tug‘ilgan yangi tug‘ilgan chaqaloqlarning klinik ko‘rsatkichlari hamda autopsiya natijalari, gistopatologik, immunogistokimyoviy va o‘pka to‘qimalarining ultrastrukturaviy xususiyatlari asosida tahlil qilindi. Asosiy makroskopik va mikroskopik topilmalar qatorida diffuz alveolyar shikastlanish (DAL), II tip pnevmositlar giperplaziyasi, interstitsial mononuklear infiltratsiya, makrofaglarning to‘planishi va immun hujayra markerlarining (CD68, CD4, CD8, FOXP3, IL-6, IL-17) o‘zgaruvchan ifodasi qayd etildi. Shu bilan birga, joriy adabiyotdagi mavjud cheklovlar yoritilib, gistologik va immunogistokimyoviy o‘zgarishlarni aks ettiruvchi sxematik jadval taqdim etildi hamda kelgusida tizimli va keng qamrovli tadqiqotlar olib borish bo‘yicha tavsiyalar ishlab chiqildi.

yangi tug‘ilgan chaqaloqSARS-CoV-2o‘pka patologiyasiimmunogistokimyoalveolyar shikastlanishII tip pnevmositlar

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APA 7 
Karimov, Rasulbek & Tajibayeva, Ma’mura (2025). MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF LUNG TISSUE IN NEWBORNS BORN TO MOTHERS INFECTED WITH COVID-19. Жанубий оролбўйи тиббиёт журнали, 1(3), 261-270.
GOST R 7.0.5 
Karimov, Rasulbek, Tajibayeva, Ma’mura MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF LUNG TISSUE IN NEWBORNS BORN TO MOTHERS INFECTED WITH COVID-19 // Жанубий оролбўйи тиббиёт журнали. 2025. Т. 1. № 3. С. 261-270.
BibTeX 
@article{rasulbek2025,
  author  = {Karimov, Rasulbek and Tajibayeva, Ma’mura},
  title   = {MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF LUNG TISSUE IN NEWBORNS BORN TO MOTHERS INFECTED WITH COVID-19},
  journal = {Жанубий оролбўйи тиббиёт журнали},
  year    = {2025},
  volume  = {1},
  number  = {3},
  pages   = {261-270}
}
RIS 
TY  - JOUR
AU  - Karimov, Rasulbek
AU  - Tajibayeva, Ma’mura
TI  - MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF LUNG TISSUE IN NEWBORNS BORN TO MOTHERS INFECTED WITH COVID-19
JO  - Жанубий оролбўйи тиббиёт журнали
PY  - 2025
VL  - 1
IS  - 3
SP  - 261
EP  - 270
ER  -