Жанубий оролбўйи тиббиёт журнали Volume 2 Issue 1 (2026) · pp. 267-270
ALLOKSANLI QANDLI DIABETDA UGLEVOD ALMASHINUVINING BUZILISHLARI
Shatursunova, Madina
Abstract
Tadqiqotning maqsadi – tajribaviy alloksan diabetining turli rivojlanish davrlarida qonda glyukoza, insulin va glikirlangan gemoglobin (HbA1c) darajasini o‘zgarishini o‘rganishdir. Natijalarda nurxat karbohid almashinuvining progressiv buzilishi, ya’ni aniq giperglikemiya, insulin sekresiyasining pasayishi va HbA1c ko‘rsatkichining sezilarli o‘sishi aniklandi. Tadqiqot davomida 40-kunda glyukoza darajasi 114%ga, HbA1c esa 138%ga oshdi; 50-kunda glyukoza 167%ga, HbA1c 483%ga; 60-kunda esa glyukoza 175%ga, HbA1c 1229%ga oshishi qayd etildi. Insulin darajasi esa mos ravishda 46%, 67% va 79%ga kamaydi. Bu alloksan diabetining model sifatida saxar diabetining patogenetik mexanizmlarini o‘rganish va yangi terapevtik usullarning samaradorligini baholash uchun yakunlanmasligini tasdiqlaydi
alloksan diabetiglyukozainsulinHbA1cFtajriba
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