Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research 7-jild 2-son (2026)
NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES
Маджидова Якутхон Набиевна, Назарова Гулнора Таджидиновна
Annotatsiya
A comprehensive clinical examination, electroneuromyography (ENMG), electromyography (EMG), biochemical tests (creatine kinase, lactate dehydrogenase, aminotransferases, troponin I), and inflammatory markers (interleukins, TNF-α) were performed in 25 patients with progressive muscular dystrophy. Creatine kinase levels were elevated in all patients, averaging 2840±1650 U/L. The highest values (4250±1980 U/L) were observed in patients with Duchenne muscular dystrophy. Electromyographic studies revealed myopathic changes in all patients: PDE amplitude was 485±180 μV, duration was 7.2±2.1 ms, and polyphasicity was 28.4±8.6%. Elevated troponin I levels were detected in 8 patients (32%). Most patients had elevated inflammatory markers (IL-1β, IL-6, TNF-α). Comprehensive diagnostics are highly effective in detecting progressive muscular dystrophy, increasing diagnostic accuracy to 92% and improving differential diagnosis of various forms of the disease.
jadallashuvchi mushak distrofiyasi, elektromiografiya, kreatinkinaza, biokimyoviy markerlar, kompleks diagnostika, neyrofiziologiyaprogressive muscular dystrophy, electromyography, creatine kinase, biochemical markers, comprehensive diagnostics, neurophysiologyjadallashuvchi mushak distrofiyasi, elektromiografiya, kreatinkinaza, biokimyoviy markerlar, kompleks diagnostika, neyrofiziologiya
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