Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research Том 7 № 2 (2026)
PROGNOSTIC FACTORS AND SURVIVAL IN RECURRENT GLIOBLASTOMA: A SYSTEMATIC REVIEW
Якубов Жахонгир Баходирович, Кариев Гайрат Маратович
Аннотация
Glioblastoma is a highly aggressive malignant brain tumor with an unfavorable prognosis. Disease recurrence is common, and survival after recurrence remains limited. Identifying prognostic factors in recurrent glioblastoma may help optimize treatment and improve clinical outcomes. This systematic review aims to analyze the clinical, molecular, and therapeutic factors that influence the survival of patients with recurrent glioblastoma. Patient age, molecular markers, and the extent of surgical resection are significant prognostic factors for survival in recurrent glioblastoma. The review results highlight the importance of molecular profiling for a personalized treatment approach. At the same time, existing salvage therapies demonstrate limited efficacy, indicating the need for the development of new therapeutic strategies to improve outcomes in this aggressive disease.
глиобластома, рецидивирующая глиобластома, прогностические факторы, выживаемостьglioblastoma, recurrent glioblastoma, prognostic factors, survival.glioblastoma, qaytalanuvchi glioblastoma, prognostik omillar, yashovchanlik.
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