Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research 7-tom 1-san (2026)
NERVE GROWTH FACTOR (NGF) AS A BIOCHEMICAL MARKER OF NEUROGENIC BLADDER DYSFUNCTION IN WOMEN WITH URGENT URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS
Махматкулов Содикжон Машраф угли, Мавлянова Зилола Фархадовна, Ашуров Рустамжон Фуркатович
Annotaciya
This article presents the results of a study examining the role of nerve growth factor (NGF) as a biochemical marker of neurogenic bladder dysfunction in women with urgency urinary incontinence (UUI) due to diabetes mellitus (DM). Eighty-six women aged 45– 65 years with UUI due to type 1 and type 2 diabetes complicated by diabetic autonomic neuropathy and 55 healthy women in the control group were examined. Urinary NGF levels were determined by enzyme-linked immunosorbent assay (ELISA) with normalization for creatinine concentration. A correlation analysis of NGF with urgency frequency, urinary incontinence episodes, total urination frequency, and the results of the validated ICIQ-SF and OAB-q questionnaires was performed. The results showed that in patients with UUI and diabetes, the level of NGF/Cr was significantly higher than in healthy women (42.8 ± 11.6 pg/mg versus 18.9 ± 6.4 pg/mg, p < 0.001), while in women with type 2 diabetes, NGF/Cr exceeded the levels in type 1 diabetes (45.1 ± 11.9 versus 37.6 ± 9.8 pg/mg, p < 0.05). Correlation analysis revealed a significant positive relationship between NGF levels and the frequency of urinary urgency (r = 0.52), episodes of UUI (r = 0.49), total urination frequency (r = 0.45), ICIQ-SF total score (r = 0.47), and OAB-q symptom scale (r = 0.54, all p < 0.05–0.01). The obtained data confirm the pathogenetic role of NGF as a marker of sensory overactivity of the bladder in women with diabetes mellitus and neurogenic bladder dysfunction.
ургентное недержание мочи, сахарный диабет, диабетическая автономная нейропатия, фактор роста нервов (NGF), нейрогенная дисфункция мочевого пузыря, ELISA, ICIQ-SF, OAB-qurge urinary incontinence, diabetes mellitus, diabetic autonomic neuropathy, nerve growth factor (NGF), neurogenic bladder dysfunction, ELISA, ICIQ-SF, OAB-qургент сийдик тутолмаслик, қандли диабет, диабетик автоном нейропатия, нерв ўсиш омили (NGF), сийдик пуфагининг нейроген дисфункцияси, ELISA, ICIQ-SF, OAB-q
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