Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research Ҷилди 7 № 3 (2026)
COMPARATIVE CHARACTERISTICS OF LEVELS OF PRO-INFLAMMATORY MEDIATORS AND MATRIX METALLOPROTEINASES IN VARIOUS ETIOLOGICAL FORMS OF CEREBRAL MICROANGIOPATHY
Адамбаев Зуфар Ибрагимович, Пазылова Аида Султановна
Аннотатсия
Cerebral microangiopathy (CSVD) represents a heterogeneous group of diseases united by damage to the small vessels of the brain but having fundamentally different mechanisms of development. This work presents a comparative analysis of key mediators of neuroinflammation (IL-1β, TNF-α) and proteolysis (MMP-9) in blood and cerebrospinal fluid (CSF) in the main etiological variants of cerebral microangiopathy: hypertensive, amyloid, diabetic, and inflammatory vasculopathy. The study covered 120 patients and 30 control subjects. The obtained data demonstrate that each etiological form is characterized by a unique mediator profile. In the hypertensive form, TNF-α dominates, reflecting systemic endothelial dysfunction; in amyloid angiopathy, a specific "blood-CSF" gradient was revealed with an extreme increase in MMP-9 in the cerebrospinal fluid, correlating with the risk of hemorrhage; in the diabetic form, a systemic increase in all mediators is observed without a pronounced gradient, while in vasculitis, extremely high values indicate immune inflammation. The established patterns open new opportunities for targeted diagnosis and personalization of therapy for cerebral microangiopathy.
церебральная микроангиопатия, болезнь мелких сосудов мозга, матриксные металлопротеиназы, ММП-9, провоспалительные цитокины, фактор некроза опухоли-α (TNF-α), интерлейкин-1β (IL-1β), воспалительные васкулиты, церебральная амилоидная ангиопатия, диабетическая микроангиопатия, нейровоспаление, деградация внеклеточного матрикса, эндотелиальная дисфункция, дифференциальная диагностика, внутримозговые кровоизлиянияcerebral microangiopathy, cerebral small vessel disease, matrix metalloproteinases, MMP-9, pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inflammatory vasculitis, cerebral amyloid angiopathy, diabetic microangiopathy, neuroinflammation, extracellular matrix degradation, endothelial dysfunction, differential diagnosis, intracerebral hemorrhagesmiya mikroangiopatiyasi, miya kichik tomir kasalligi, matritsa metalloproteinalari, MMP-9, pro-yallashuv sitokinlari, o‘smalar nekrozi omili-α (TNF-α), interleykin-1β (IL-1β), yallashuvli vaskulitlar, miya amiloid angiopatiyasi, diabetik mikroangiopatiya, neyro-yallashuv, hujayra tashqi matritsasining degeneratsiyasi, endotelial disfunksiya, differensial diagnostika, intraserebral qon ketishlar
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