Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research Volume 7 Issue 4 (2026)
AWAKE CRANIOTOMY FOR PATIENTS WITH RECURRENT GLIOMAS. A REVIEW OF LITERATURE
Мамадалиев Дилшод Мухаммадвалиевич, Асадуллаев Улуғбек Максудович, Кариев Гайрат Маратович, Якубов Жахонгир Баходирович, Maтмусаев Маъруф Махсудович, Ахмедиев Тохир Махмудович
Abstract
This systematic review was conducted according to the PRISMA 2020 guidelines to identify English-language studies published within the past 5 years (2020–2025) reporting awake craniotomy (with intraoperative mapping) for repeat resection of recurrent glioblastoma in adult patients (≥18 years). PubMed/MEDLINE, Embase, Scopus, and Web of Science were searched. We included retrospective or prospective series with ≥3 patients and excluded techniques performed in a non-awake state, histology other than glioblastoma, non-recurrent resections, and publications not in English. Extracted data included sample size, mapping success, resection extent (EOR/GTR), neurological deficit rate (transient/permanent), PFS, OS, and follow-up duration. Specifically, we focused on articles in which authors evaluated and compared the risk-benefit ratio of awake surgery for recurrent cases. Only articles in English were analyzed. Results: A search of the current literature identified 340 records (original articles and case series). After removing 46 duplicates, 294 records were screened by title/ANNOTATION, of which 250 were excluded. Forty-four full-text articles were assessed for inclusion criteria; 36 were excluded (20 due to non-recurrent glioblastoma, 8 due to insufficient data, 4 due to duplicate datasets, and 4 due to non-English language). Ultimately, 8 studies met the inclusion criteria for qualitative synthesis; of these, 5 provided sufficient data for quantitative synthesis (meta-analysis).
рецидивирующая глиома, нейрофизиологическое картирование, хирургия в сознанииrecurrent glioma, neurophysiological mapping, awake surgeryқайталанувчи глиомалар, интраоперацион нейрофизиологик хариталаш, уйғоқ жарроҳлик
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