Вестник Ассоциации пульмонологов Центральной Азии Ҷилди 12 № 7 (2025) · Саҳифаҳои 76-79
INNOVATIVE METHODS OF PYELONEPHRITIS DIAGNOSTICS IN CHILDREN
Akhmedzhanova N.I., Gapparova G.N., Akhmatova Y.A., Ismailova Z.A.
Аннотатсия
Pyelonephritis is the second most common disease in children after acute respiratory infections, and there is a clear and close relationship between them. Objective. Determination of clinical and laboratory features of early diagnosis of pyelonephritis in children who have had COVID-19. Methods. An observational cohort retrospective clinical study of 121 children with pyelonephritis was conducted. Results and discussion. We analyzed changes in partial renal function in all patients with pyelonephritis. The results of the study indicate that in patients of groups 1 and 3, all studied clinical and laboratory parameters were significantly impaired compared to group 2. These changes confirm that they can manifest themselves differently depending on the causes of the disease (etiological factors). Conclusion. In patients with pyelonephritis who had COVID-19, damage was found not only to the proximal (proteinuria increased 11 times compared to healthy children) and distal tubules (ammoniogenesis function decreased by 34%) of the renal nephrons, but also damage to the glomeruli (GFR decreased by 38% compared to healthy children), which is not typical for pyelonephritis in children without a history of COVID-19.
COVID-19, acute pyelonephritis, KIM-1, β2-microglobulin levels.
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