Вестник Ассоциации пульмонологов Центральной Азии 14-том 9-нөмір (2025) · 216-224-беттер
HEPATITIS «C» AND «B» CO-INFECTION: IMPACT ON TREATMENT OUTCOMES IN MDR-TB PATIENTS
Mamatov L.B., Abdugapparov F.B., Eshmuradov X.I.
Аңдатпа
Dual infections of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant tuberculosis (RR-TB) and hepatitis C virus (HCV) have resulted in nearly half a million cases of MDR-TB annually worldwide and 71 million people living with HCV. Aim of the study to analyze the features of the course of MDR-TB when combined with viral hepatitis “C” and “B”. We examined 354 MDR-TB patients aged from 20 to 70 years who were undergoing inpatient treatment in the 2-therapeutic department of the Tashkent City Clinical Hospital of Phthisiology and Pulmonology (TCCHPhP) in the city of Tashkent in 2021-2023. It was found that out of 354 patients, 86 (24.3%) were diagnosed with viral hepatitis. Accordingly, the development included 86 patients with co-infection with MDR-TB and viral hepatitis. Of these, 21 (24.4%) were newly diagnosed patients, 65 (75.6%) were previously treated. The spectrum of viral hepatitis was as follows: 75 patients had viral hepatitis C (87.2%), 5 patients had a combination of viral hepatitis “C” and “B” (5.8%) and 6 had viral hepatitis “B” (7%). Among those examined, the social characteristics of the patients played an important role. Thus, the bulk were unemployed—77 (89.5%). Workers and employees account for only 9 (10.5 %) people. 53 people had a criminal record, which accounted for 61.6% of patients. Persons without a fixed place of residence made up 17 (19.7%) patients. Almost all patients had secondary education - 77 (89.5%), 9 (10.5%) patients had higher education. All patients had bad habits: smoking was noted in 60 (69.7%) patients, alcohol abuse - in 52 (60.4%), injecting drugs - 16 (18.6%) and nasvay use - in 6 (6.9%). Moreover, more than half of the patients had two or three bad habits - 49 (56.9%). In conclusion the study of medical and social characteristics made it possible to establish that patients with MDR/RR tuberculosis in combination with viral hepatitis belong in most cases to a socially maladjusted contingent (76.2%). The presence of bad habits, and in more than half of the cases two or three, as well as the presence of a criminal record (61.6%), persons without a fixed place of residence (19.7 %), alcohol abuse (60.4%), injection drugs use (18.6%) significantly affects the treatment process.
MDR-TB, viral hepatitis “C” and “B”, TB treatment outcome
Метадеректер дереккөзі: журналдың OAI-PMH архиві · Sindex толық мәтінді сақтамайды, дереккөзге сілтеме береді.