Товарлар кимёси ва халқ табобати Volume 4 Issue 3 (2025) · pp. 68-77

INNOVATIVE ANTIMICROBIAL STRATEGIES USING CARBON NANOZYMES AND PHOSPHATASE INHIBITORS: SYNERGISTIC EFFECTS AND MECHANISTIC INSIGHTS

Benassi, Enrico, Fan, Haiyan

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Abstract

This study introduces novel approaches against multidrug-resistant bacteria using nanozymes and phosphatase inhibitors. Beet-derived SN-CNPs exhibited robust phosphatase-like activity and selectively disrupted bacterial membranes, while sodium orthovanadate (SOV) inhibited phosphatases essential for cell wall synthesis, exerting bactericidal effects. Combined application of SN-CNPs and SOV enhanced antimicrobial efficacy against E. coli and L. lactis, highlighting a synergistic mechanism. The findings underscore phosphatase-centered strategies as a paradigm shift from conventional ROS-dependent therapies and open new avenues for multi-targeted antimicrobial interventions.

multidrug-resistant bacteriananozymesphosphatase inhibitorSN-CNPSOVsynergyantimicrobial therapyмножественная лекарственная устойчивостьнанозимыингибитор фосфатазы

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Cite

APA 7 
Benassi, Enrico & Fan, Haiyan (2025). INNOVATIVE ANTIMICROBIAL STRATEGIES USING CARBON NANOZYMES AND PHOSPHATASE INHIBITORS: SYNERGISTIC EFFECTS AND MECHANISTIC INSIGHTS. Товарлар кимёси ва халқ табобати, 4(3), 68-77.
GOST R 7.0.5 
Benassi, Enrico, Fan, Haiyan INNOVATIVE ANTIMICROBIAL STRATEGIES USING CARBON NANOZYMES AND PHOSPHATASE INHIBITORS: SYNERGISTIC EFFECTS AND MECHANISTIC INSIGHTS // Товарлар кимёси ва халқ табобати. 2025. Т. 4. № 3. С. 68-77.
BibTeX 
@article{enrico2025,
  author  = {Benassi, Enrico and Fan, Haiyan},
  title   = {INNOVATIVE ANTIMICROBIAL STRATEGIES USING CARBON NANOZYMES AND PHOSPHATASE INHIBITORS: SYNERGISTIC EFFECTS AND MECHANISTIC INSIGHTS},
  journal = {Товарлар кимёси ва халқ табобати},
  year    = {2025},
  volume  = {4},
  number  = {3},
  pages   = {68-77}
}
RIS 
TY  - JOUR
AU  - Benassi, Enrico
AU  - Fan, Haiyan
TI  - INNOVATIVE ANTIMICROBIAL STRATEGIES USING CARBON NANOZYMES AND PHOSPHATASE INHIBITORS: SYNERGISTIC EFFECTS AND MECHANISTIC INSIGHTS
JO  - Товарлар кимёси ва халқ табобати
PY  - 2025
VL  - 4
IS  - 3
SP  - 68
EP  - 77
ER  -