Товарлар кимёси ва халқ табобати 4-том 3-нөмір (2025) · 68-77-беттер
INNOVATIVE ANTIMICROBIAL STRATEGIES USING CARBON NANOZYMES AND PHOSPHATASE INHIBITORS: SYNERGISTIC EFFECTS AND MECHANISTIC INSIGHTS
Benassi, Enrico, Fan, Haiyan
Аңдатпа
This study introduces novel approaches against multidrug-resistant bacteria using nanozymes and phosphatase inhibitors. Beet-derived SN-CNPs exhibited robust phosphatase-like activity and selectively disrupted bacterial membranes, while sodium orthovanadate (SOV) inhibited phosphatases essential for cell wall synthesis, exerting bactericidal effects. Combined application of SN-CNPs and SOV enhanced antimicrobial efficacy against E. coli and L. lactis, highlighting a synergistic mechanism. The findings underscore phosphatase-centered strategies as a paradigm shift from conventional ROS-dependent therapies and open new avenues for multi-targeted antimicrobial interventions.
multidrug-resistant bacteriananozymesphosphatase inhibitorSN-CNPSOVsynergyantimicrobial therapyмножественная лекарственная устойчивостьнанозимыингибитор фосфатазы
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