Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali Ҷилди 4 № 4 (2023)
STUDY OF THE CLINICAL EFFICACY OF ORAL DIRECT ANTICOAGULANTS IN PATIENTS WITH ATRIAL FIBRILLATION
Исмаилов Джамшид Абдураимович, Хамраев Фарид Хамидуллаевич, Хамидуллаев Фирдавс Фаридович, Расули Фарида Орифовна, Тураев Хикматилла Негматович
Аннотатсия
To study the clinical efficacy and safety of direct-acting oral anticoagulants in patients with atrial fibrillation treated in a real clinical setting. In this study, 356 AF patients aged 50 to 75 years with a creatinine clearance rate of at least 50 ml/min were observed. Patients were divided into 3 groups according to the type of POAC taken: Group 1 (n=120) took rivaroxaban at a dose of 20 mg/1 g/day; Group 2 (n=112) took dabigatran etexilate at a dose of 150 g/day mg/1 g/day 2 times a day; and Group 3 (n=124) took apixaban at a dose of 5 mg/2 times a day. The groups of patients were compared by age, concomitant pathology, risk of thromboembolic and hemorrhagic complications. The study period was 2 years from the time of drug administration. The endpoints were thromboembolic complications, major bleeding events and death from any cause.
фибрилляция предсердий, пероральные антикоагулянты, тромбоэмболические осложнения, инфаркт, инсультatrial fibrillation, oral anticoagulants, thromboembolic complications, infarction, strokeatriyal fibrilatsiya, og'iz antikoagulyantlari, tromboembolik asoratlar, yurak xuruji, qon tomir
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