Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Volume 7 Issue 4 (2022)

INFLUENCE OF CALCIUM CHANNEL ANTAGONISTS ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS IN RATS.

ХАКИМОВ Зиявиддин Зайнутдинович, РАХМАНОВ Алишер Худайбердиевич, БЕКОВА Нодира Бахадировна

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Abstract

The preventive effect of calcium channel blockers at adjuvant-induced arthritis on the course of chronic arthritis, hematological blood parameters, as well as on the content of cytokines and C-reactive protein was studied in sexually mature male rats weighing 140-160 g. It has been established that calcium channel antagonists have an inhibitory effect on the development of adjuvant-induced arthritis, especially diltiazem and cinnarizine, which have an almost identical effect to diclofenac sodium. A more pronounced correction of violations of hematological parameters was observed in animals receiving prophylactic diltiazem. One of the mechanisms of the antiflagogenic action of calcium channel blockers is a decrease in the level of pro-inflammatory and an increase in anti-inflammatory interleukins.

адъювант индуцированный артрит, антагонисты кальциевых каналов, гематология, цитокиныadjuvant-induced arthritis, calcium channel antagonists, hematology, cytokines.адъювант билан чақирилган артрит, кальций канали антагонистлари, гематология, цитокинлар

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Cite

APA 7 
ХАКИМОВ Зиявиддин Зайнутдинович, РАХМАНОВ Алишер Худайбердиевич & БЕКОВА Нодира Бахадировна (2022). INFLUENCE OF CALCIUM CHANNEL ANTAGONISTS ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS IN RATS.. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4).
GOST R 7.0.5 
ХАКИМОВ Зиявиддин Зайнутдинович, РАХМАНОВ Алишер Худайбердиевич, БЕКОВА Нодира Бахадировна INFLUENCE OF CALCIUM CHANNEL ANTAGONISTS ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS IN RATS. // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2022. Т. 7. № 4.
BibTeX 
@article{зайнутдинович2022,
  author  = {ХАКИМОВ Зиявиддин Зайнутдинович and РАХМАНОВ Алишер Худайбердиевич and БЕКОВА Нодира Бахадировна},
  title   = {INFLUENCE OF CALCIUM CHANNEL ANTAGONISTS ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS IN RATS.},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2022},
  volume  = {7},
  number  = {4}
}
RIS 
TY  - JOUR
AU  - ХАКИМОВ Зиявиддин Зайнутдинович
AU  - РАХМАНОВ Алишер Худайбердиевич
AU  - БЕКОВА Нодира Бахадировна
TI  - INFLUENCE OF CALCIUM CHANNEL ANTAGONISTS ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS IN RATS.
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2022
VL  - 7
IS  - 4
ER  -