Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 7-jild 4-son (2022)
INFLUENCE OF CALCIUM CHANNEL ANTAGONISTS ON THE DEVELOPMENT OF ADJUVANT ARTHRITIS IN RATS.
ХАКИМОВ Зиявиддин Зайнутдинович, РАХМАНОВ Алишер Худайбердиевич, БЕКОВА Нодира Бахадировна
Annotatsiya
The preventive effect of calcium channel blockers at adjuvant-induced arthritis on the course of chronic arthritis, hematological blood parameters, as well as on the content of cytokines and C-reactive protein was studied in sexually mature male rats weighing 140-160 g. It has been established that calcium channel antagonists have an inhibitory effect on the development of adjuvant-induced arthritis, especially diltiazem and cinnarizine, which have an almost identical effect to diclofenac sodium. A more pronounced correction of violations of hematological parameters was observed in animals receiving prophylactic diltiazem. One of the mechanisms of the antiflagogenic action of calcium channel blockers is a decrease in the level of pro-inflammatory and an increase in anti-inflammatory interleukins.
адъювант индуцированный артрит, антагонисты кальциевых каналов, гематология, цитокиныadjuvant-induced arthritis, calcium channel antagonists, hematology, cytokines.адъювант билан чақирилган артрит, кальций канали антагонистлари, гематология, цитокинлар
Metadata manbasi: jurnal OAI-PMH arxivi · Sindex toʻliq matnni saqlamaydi, manbaga havola beradi.