Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Том 10 № 6 (2025)

IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY

БИЛАЛОВ Баходир Эркинович, НИШАНОВ Данияр Анарбаевич, БИЛАЛОВ Эркин Назимович, ОРИПОВ Окилхон Ильясович, CУЛТАНОВ Озод Абдулла угли

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Аннотация

Objective. To evaluate the antifibrotic efficacy of sodium carboxymethylcellulose (Na-CMC)-based hydrogel in experimental antiglaucomatous surgery using immunohistochemical (IHC) markers Ki-67 and desmin. Materials and Methods. The experiment was conducted on 36 rabbits (72 eyes) divided into three groups: control (no barrier material), comparative (Omnivisc viscoelastic), and experimental (Na-CMC hydrogel). Histological and IHC examinations were performed at designated time points following deep sinus trabeculoiridectomy. Expression levels of Ki-67 and desmin were used to assess cellular proliferation and myofibroblastic transformation. Results. In the control group, high expression levels of Ki-67 and desmin (up to 67%) indicated active fibrotic processes. The application of Na-CMC hydrogel significantly reduced the expression of both markers to near-physiological levels (Ki-67: 20.0±2.0%; desmin: 12.5±1.5%), suggesting effective suppression of inflammatory and fibrotic activity. Conclusion. Na-CMC hydrogel demonstrates a pronounced antifibrotic effect and may serve as a safe alternative to toxic antifibrotic agents in glaucoma surgery.

глаукома, послеоперационный фиброз, Na-КМЦ, иммуногистохимияglaucoma, postoperative fibrosis, Na-CMC, immunohistochemistryglaukoma, operatsiyadan keyingi fibroz, Na-KMS, immunogistokimyo

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APA 7 
БИЛАЛОВ Баходир Эркинович, НИШАНОВ Данияр Анарбаевич, БИЛАЛОВ Эркин Назимович, ОРИПОВ Окилхон Ильясович & CУЛТАНОВ Озод Абдулла угли (2025). IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6).
GOST R 7.0.5 
БИЛАЛОВ Баходир Эркинович, НИШАНОВ Данияр Анарбаевич, БИЛАЛОВ Эркин Назимович, ОРИПОВ Окилхон Ильясович, CУЛТАНОВ Озод Абдулла угли IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2025. Т. 10. № 6.
BibTeX 
@article{эркинович2025,
  author  = {БИЛАЛОВ Баходир Эркинович and НИШАНОВ Данияр Анарбаевич and БИЛАЛОВ Эркин Назимович and ОРИПОВ Окилхон Ильясович and CУЛТАНОВ Озод Абдулла угли},
  title   = {IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2025},
  volume  = {10},
  number  = {6}
}
RIS 
TY  - JOUR
AU  - БИЛАЛОВ Баходир Эркинович
AU  - НИШАНОВ Данияр Анарбаевич
AU  - БИЛАЛОВ Эркин Назимович
AU  - ОРИПОВ Окилхон Ильясович
AU  - CУЛТАНОВ Озод Абдулла угли
TI  - IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2025
VL  - 10
IS  - 6
ER  -